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Chapter one - Introduction: Organic Chemistry in the Nineteenth Century
Pages 1-13 - Book chapterAbstract only
Chapter TWO - Vladimir Vasil'evich Markovnikov and his rule for addition
Pages 15-53 - Book chapterAbstract only
Chapter Three - Markovnikov's rule: history and development
Pages 55-72 - Book chapterAbstract only
Chapter Four - Aleksandr Mikhailovich Zaitsev and his empirical rule for elimination
Pages 73-109 - Book chapterAbstract only
Chapter Five - August Wilhelm von Hofmann and Hofmann's rule for elimination
Pages 111-138 - Book chapterAbstract only
Chapter Six - Paul Walden and the Walden inversion
Pages 139-160 - Book chapterAbstract only
Chapter Seven - Mechanistic studies
Pages 161-195 - Book chapterAbstract only
Chapter Eight - Development of highly regioselective addition reactions of alkenes and alkynes
Pages 197-228 - Book chapterAbstract only
Chapter Nine - Development of highly regiospecific alkene syntheses: elimination and its substitutes
Pages 229-243 - Book chapterAbstract only
Chapter Ten - Inversion of configuration in modern synthesis
Pages 245-266 - Book chapterNo access
Index
Pages 267-271
About the book
Description
Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.
Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.
Key Features
- Introduces Markovnikov, Zaitsev, Hofmann, and Walden as actual persons, rather than just an abstract term used as a form of short-hand to describe the rules
- Discusses, in depth, the discovery and usage of these reactions and rules, from their discovery to their most recent applications
- Includes biographical materials about chemists responsible for major changes in application of the rules
- Traces the history of the applications of these reactions, e.g., anti-Markovnikov additions in catalytic organic synthesis, and reactions such as the Mitsunobu reaction improving the original SN2 displacement
- Introduces Markovnikov, Zaitsev, Hofmann, and Walden as actual persons, rather than just an abstract term used as a form of short-hand to describe the rules
- Discusses, in depth, the discovery and usage of these reactions and rules, from their discovery to their most recent applications
- Includes biographical materials about chemists responsible for major changes in application of the rules
- Traces the history of the applications of these reactions, e.g., anti-Markovnikov additions in catalytic organic synthesis, and reactions such as the Mitsunobu reaction improving the original SN2 displacement
Details
ISBN
978-0-12-821027-7
Language
English
Published
2022
Copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Imprint
Elsevier